In:Understanding Language and Cognition through Bilingualism: In honor of Ellen Bialystok
Edited by Gigi Luk, John A.E. Anderson and John G. Grundy
[Studies in Bilingualism 64] 2023
► pp. 343–356
Chapter 16Role of bilingualism
in neurodegenerative disease I
Alzheimer’s
Published online: 6 June 2023
https://doi.org/10.1075/sibil.64.16sha
https://doi.org/10.1075/sibil.64.16sha
Abstract
Recent research shows bilingualism to be a
reserve factor, delaying the onset of symptoms of dementia and
slowing the rate at which cognitive decline progresses. This chapter
explores how bilingualism may affect the progression of Alzheimer’s
disease and why bilingual individuals are more resilient to the
effects of Alzheimer’s pathology. The chapter starts with an
overview of bilingualism, then leads into how bilingualism acts as a
possible mechanism of cognitive reserve. We consider bilingual
experience to be a factor of cognitive reserve from three
perspectives: pathological symptoms, neuroimaging, and biomarkers.
Collectively, bilingualism appears to be beneficial for delaying
symptoms, slowing progression, and maintaining cognitive functioning
in the face of Alzheimer’s disease. The chapter ends with
conclusions based on the research to-date and outlines possible
implications for future research.
Article outline
- Preamble
- Introduction
- Definition of bilingualism
- Mechanisms of cognitive reserve
- Effects of bilingualism on delaying onset of AD
- Imaging studies of bilingualism in AD
- Biomarker studies of bilingualism in AD
- Conclusion
References Appendix
References (48)
Abutalebi, J., Canini, M., Della Rosa, P. A., Green, D. W., & Weekes, B. S. (2015). The
neuroprotective effects of bilingualism upon the inferior
parietal lobule: A structural neuroimaging study in aging
Chinese bilinguals. Journal
of
Neurolinguistics, 33, 3–13.
Albán-González, G., & Ortega-Campoverde, T. (2014). Relationship
between bilingualism and
Alzheimer’s. Suma de
Negocios, 5(11), 126–133.
Alcolea, D., Martínez-Lage, P., Sánchez-Juan, P., Olazarán, J., Antúnez, C., Izagirre, A., Ecay-Torres, M., Estanga, A., Clerigué, M., Guisasola, M. C., Sánchez Ruiz, D., Marín Muñoz, J., Calero, M., Blesa, R., Clarimón, J., Carmona-Iragui, M., Morenas-Rodríguez, E., Rodríguez-Rodríguez, E., Vázquez Higuera, J. L., … Lleó, A. (2015). Amyloid
precursor protein metabolism and inflammation markers in
preclinical Alzheimer
disease. Neurology, 85(7), 626–633.
Alladi, S., Bak, T. H., Duggirala, V., Surampudi, B., Shailaja, M., & Shukla, A. K. (2013). Bilingualism
delays age at onset of dementia, independent of education
and immigration
status. Neurology, 81(22), 1938–1944.
Anderson, J. A. E., Grundy, J. G., De Frutos, J., Barker, R. M., Grady, C., & Bialystok, E. (2018). Effects
of bilingualism on white matter integrity in older
adults. NeuroImage, 167, 143–150.
Anderson, J. A. E., Hawrylewicz, K., & Grundy, J. G. (2020). Does
bilingualism protect against dementia? A
meta-analysis. Psychonomic
Bulletin &
Review, 27(5), 952–965.
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019). Diagnosis
and management of dementia:
Review. JAMA, 322(16), 1589–1599.
Bak, T. H., Nissan, J. J., Allerhand, M. M., & Deary, I. J. (2014). Does
bilingualism influence cognitive aging? Bilingualism and
aging. Annals of
Neurology, 75(6), 959–963.
Berkes, M., Bialystok, E., Craik, F. I. M., Troyer, A., & Freedman, M. (2020). Conversion
of mild cognitive impairment to Alzheimer disease in
monolingual and bilingual
patients. Alzheimer Disease
& Associated
Disorders, 34(3), 225–230.
Bialystok, E. (2010). Global-local
and trail-making tasks by monolingual and bilingual
children: Beyond
inhibition. Developmental
Psychology, 46(1), 93–105.
(2011). Reshaping
the mind: The benefits of
bilingualism. Canadian
Journal of Experimental Psychology/Revue Canadienne de
Psychologie
Expérimentale, 65(4), 229–235.
Bialystok, E., Craik, F. I. M., Binns, M. A., Ossher, L., & Freedman, M. (2014). Effects
of bilingualism on the age of onset and progression of MCI
and AD: Evidence from executive function
tests. Neuropsychology, 28(2), 290–304.
Bialystok, E., Craik, F. I. M., & Freedman, M. (2007). Bilingualism
as a protection against the onset of symptoms of
dementia. Neuropsychologia, 45(2), 459–464.
Bialystok, E., Craik, F., & Luk, G. (2008). Cognitive
control and lexical access in younger and older
bilinguals. Journal of
Experimental Psychology. Learning, Memory, and
Cognition, 34(4), 859–873.
Calvo, N., García, A. M., Manoiloff, L., & Ibáñez, A. (2016). Bilingualism
and cognitive reserve: A critical overview and a plea for
methodologicaliInnovations. Frontiers
in Aging
Neuroscience, 7.
Craik, F. I. M., Bialystok, E., & Freedman, M. (2010). Delaying
the onset of Alzheimer disease: Bilingualism as a form of
cognitive
reserve. Neurology, 75(19), 1726–1729.
Duncan, H. D., Nikelski, J., Pilon, R., Steffener, J., Chertkow, H., & Phillips, N. A. (2018). Structural
brain differences between monolingual and multilingual
patients with mild cognitive impairment and Alzheimer
disease: Evidence for cognitive
reserve. Neuropsychologia, 109, 270–282.
Estanga, A., Ecay-Torres, M., Ibañez, A., Izagirre, A., Villanua, J., Garcia-Sebastian, M., Iglesias Gaspar, M. T., Otaegui-Arrazola, A., Iriondo, A., Clerigue, M., & Martinez-Lage, P. (2017). Beneficial
effect of bilingualism on Alzheimer’s disease CSF biomarkers
and cognition. Neurobiology
of
Aging, 50, 144–151.
Fischer, C. E., & Schweizer, T. A. (2014). How
does speaking another language reduce the risk of
dementia? Expert Review of
Neurotherapeutics, 14(5), 469–471.
Frisoni, G. B., Geroldi, C., Beltramello, A., Bianchetti, A., Binetti, G., Bordiga, G., DeCarli, C., Laakso, M. P., Soininen, H., Testa, C., Zanetti, O., & Trabucchi, M. (2002). Radial
width of the temporal horn: A sensitive measure in Alzheimer
disease. American Journal of
Neuroradiology, 23(1), 35–47.
Frutos-Lucas, J. de, López-Sanz, D., Cuesta, P., Bruña, R., la Fuente, S. de, Serrano, N., López, M. E., Delgado-Losada, M. L., López-Higes, R., Marcos, A., & Maestú, F. (2019). Enhancement
of posterior brain functional networks in bilingual older
adults. Bilingualism:
Language and
Cognition, 23(2), 387–400.
Gold, B. T. (2015). Lifelong
bilingualism and neural reserve against Alzheimer’s disease:
A review of findings and potential
mechanisms. Behavioural Brain
Research, 281, 9–15.
Gollan, T. H., Salmon, D. P., Montoya, R. I., & Galasko, D. R. (2011). Degree
of bilingualism predicts age of diagnosis of Alzheimer’s
disease in low-education but not in highly educated
Hispanics. Neuropsychologia, 49(14), 3826–3830.
Grundy, J. G., & Anderson, J. A. E. (2017). Commentary:
The relationship of bilingualism compared to monolingualism
to the risk of cognitive decline or dementia: A systematic
review and
meta-analysis. Frontiers in
Aging
Neuroscience, 9, 344.
Klein, R. M., Christie, J., & Parkvall, M. (2016). Does
multilingualism affect the incidence of Alzheimer’s disease?
A worldwide analysis by
country. SSM – Population
Health, 2, 463–467.
Klimova, B., Valis, M., & Kuca, K. (2017). Bilingualism
as a strategy to delay the onset of Alzheimer’s
disease. Clinical
Interventions in
Aging, 12, 1731–1737.
Kowoll, M. E., Degen, C., Gladis, S., & Schröder, J. (2015). Neuropsychological
profiles and verbal abilities in lifelong bilinguals with
mild cognitive impairment and Alzheimer’s
disease. Journal of
Alzheimer’s
Disease, 45(4), 1257–1268.
Kowoll, M. E., Degen, C., Gorenc, L., Küntzelmann, A., Fellhauer, I., Giesel, F., Haberkorn, U., & Schröder, J. (2016). Bilingualism
as a contributor to cognitive reserve? Evidence from
cerebral glucose metabolism in mild cognitive impairment and
Alzheimer’s
disease. Frontiers in
Psychiatry, 7.
Luk, G., Bialystok, E., Craik, F. I. M., & Grady, C. L. (2011). Lifelong
bilingualism maintains white matter integrity in older
adults. Journal of
Neuroscience, 31(46), 16808–16813.
Navon, D. (1977). Forest
before trees: The precedence of global features in visual
perception. Cognitive
Psychology, 9(3), 353–383.
Ossher, L., Bialystok, E., Craik, F. I. M., Murphy, K. J., & Troyer, A. K. (2013). The
effect of bilingualism on amnestic mild cognitive
impairment. The Journals of
Gerontology Series B: Psychological Sciences and Social
Sciences, 68(1), 8–12.
Paulavicius, A. M., Mizzaci, C. C., Tavares, D. R. B., Rocha, A. P., Civile, V. T., Schultz, R. R., Pinto, A. C. P. N., & Trevisani, V. F. M. (2020). Bilingualism
for delaying the onset of Alzheimer’s disease: A systematic
review and
meta-analysis. European
Geriatric
Medicine, 11(4), 651–658.
Perani, D., & Abutalebi, J. (2015). Bilingualism,
dementia, cognitive and neural reserve: Current
Opinion in
Neurology, 28(6), 618–625.
Perani, D., Farsad, M., Ballarini, T., Lubian, F., Malpetti, M., Fracchetti, A., Magnani, G., March, A., & Abutalebi, J. (2017). The
impact of bilingualism on brain reserve and metabolic
connectivity in Alzheimer’s
dementia. Proceedings of the
National Academy of
Sciences, 114(7), 1690–1695.
Rodríguez-Pujadas, A., Sanjuán, A., Fuentes, P., Ventura-Campos, N., Barrós-Loscertales, A., & Ávila, C. (2014). Differential
neural control in early bilinguals and monolinguals during
response inhibition. Brain
and
Language, 132, 43–51.
Schweizer, T. A., Ware, J., Fischer, C. E., Craik, F. I. M., & Bialystok, E. (2012). Bilingualism
as a contributor to cognitive reserve: Evidence from brain
atrophy in Alzheimer’s
disease. Cortex, 48(8), 991–996.
Smirnov, D. S., Stasenko, A., Salmon, D. P., Galasko, D., Brewer, J. B., & Gollan, T. H. (2019). Distinct
structural correlates of the dominant and nondominant
languages in bilinguals with Alzheimer’s disease
(AD). Neuropsychologia, 132, 107131.
Steffener, J., Reuben, A., Rakitin, B. C., & Stern, Y. (2011). Supporting
performance in the face of age-related neural changes:
Testing mechanistic roles of cognitive
reserve. Brain Imaging and
Behavior, 5(3), 212–221.
Stern, Y. (2002). What
is cognitive reserve? Theory and research application of the
reserve concept. Journal of
the International Neuropsychological
Society, 8(3), 448–460.
Stern, Y., Arenaza-Urquijo, E. M., Bartrés-Faz, D., Belleville, S., Cantilon, M., Chetelat, G., Ewers, M., Franzmeier, N., Kempermann, G., Kremen, W. S., Okonkwo, O., Scarmeas, N., Soldan, A., Udeh-Momoh, C., Valenzuela, M., Vemuri, P., Vuoksimaa, E., & and the
Reserve, Resilience and Protective Factors PIA Empirical
Definitions and Conceptual Frameworks
Workgroup. (2020). Whitepaper:
Defining and investigating cognitive reserve, brain reserve,
and brain
maintenance. Alzheimer’s
&
Dementia, 16(9), 1305–1311.
Voits, T., Robson, H., Rothman, J., & Pliatsikas, C. (2020). The
effects of bilingualism on the structure of the hippocampus
and on memory performance in ageing
bilinguals. PsyArXiv
Preprints.
Waldie, K. E., Badzakova-Trajkov, G., Miliivojevic, B., & Kirk, I. J. (2009). Neural
activity during Stroop colour-word task performance in late
proficient bilinguals: A functional magnetic resonance
imaging study. Psychology
&
Neuroscience, 2(2), 125–136.
Wei, R., Li, C., Fogelson, N., & Li, L. (2016). Prediction
of conversion from mild cognitive impairment to Alzheimer’s
disease using MRI and structural network
features. Frontiers in Aging
Neuroscience, 8.
Weigmann, K. (2014). The
Babylonian benefit: Neurological research shows that being
bilingual enhances mental performance and may protect from
Alzheimer’s disease. EMBO
Reports, 15(10), 1015–1018.