In:Quantitative Methods in Multilingual Acquisition and Processing
Edited by Gabrielle Klassen and John W. Schwieter
[Research Methods in Applied Linguistics 16] 2026
► pp. 227–248
Chapter 11Neural imaging (PET, MEG, and fMRI) as a window into language development
and processing
Published online: 26 March 2026
https://doi.org/10.1075/rmal.16.11ras
https://doi.org/10.1075/rmal.16.11ras
Abstract
This chapter reviews Second Language Acquisition (SLA)
studies utilizing positron emission tomography (PET), magnetoencephalography
(MEG), and functional magnetic resonance imaging (fMRI). fMRI tracks the
changes in the metabolism of neurons when a language-related task is
performed. It tells us how much glucose is transported to the neurons in
brain tissues, and therefore the likelihood that those neurons are active or
not through the analysis of how oxygenated the tissue is. PET too measures
regional cerebral blood flow but — unlike the fMRI — tracks the distribution
of a radioactive isotope injected into the research subject’s bloodstream,
as it is carried up into their brain. Magnetoencephalography (MEG) records
tiny magnetic fields on the scalp which are time-locked to the presentation
of language stimuli. The chapter describes the most utilized experimental
paradigms, their strengths, and weaknesses. Research questions that are
targeted by neuroimaging SLA studies concern: (a) whether native speakers
and L2 learners activate the same brain areas (b) whether activation
patterns vary depending on the language domain (syntax, phonology,
semantics); (c) whether L1–L2 differences, proficiency and writing systems
modulate those patterns.
Article outline
- 11.1Introduction
- 11.2Positron emission tomography (PET)
- 11.2.1The technique
- 11.2.2Experimental evidence
- 11.3Magnetoencephalography (MEG)
- 11.3.1The technique
- 11.3.2Experimental evidence
- 11.3.3Summary
- 11.4Functional magnetic resonance imaging (fMRI)
- 11.4.1The technique
- 11.4.2Experimental evidence: Lexico-semantics, grammar and phonology
- 11.4.3L1–L2 typological distance and writing systems
- 11.4.4Classroom instruction and the role of the inferior parietal lobe (IPL) before and after training
- 11.4.5fMRI in individuals and across groups
- 11.5Conclusion
Notes References
References (67)
Anand, S. S., Singh, H., & Dash, A. K. (2009). Clinical
applications of PET and
PET-CT. Medical journal, Armed Forces
India, 65(4), 353–358.
Anurova, I., & Immonen, P. (2017). Native
vs. second language discrimination in the modulation of the
N400/N400m. European Journal of
Neuroscience, 45(10), 1289–1299.
Barbeau, E. B., Chai, X. J., Chen, J. K., Soles, J., Berken, J., Baum, S., Watkins, K. E., & Klein, D. (2017). The
role of the left inferior parietal lobule in second language
learning: An intensive language training fMRI
study. Neuropsychologia, 98, 169–176.
Bastarrika, A., & Davidson, D. J. (2017). An
event-related field study of rapid grammatical plasticity in adult
second-language learners. Frontiers
in Human
Neuroscience, 11.
Blanco-Elorrieta, E., & Pylkkänen, L. (2016). Bilingual
language control in perception versus action: MEG reveals
comprehension control mechanisms in anterior cingulate cortex and
domain-general control of production in dorsolateral prefrontal
cortex. Journal of
Neuroscience, 36(2), 290–301.
(2017). Bilingual
language switching in the laboratory versus in the wild: The
spatiotemporal dynamics of adaptive language
control. The Journal of
Neuroscience, 37(37), 9022–9036.
Blanco-Elorrieta, E., Emmorey, K., & Pylkkänen, L. (2018). Language
switching decomposed through MEG and evidence from bimodal
bilinguals. Proceedings of the
National Academy of
Sciences, 115(39), 9708–9713.
Blumenfeld, H. (2021). Neuroanatomy
through clinical cases (3rd
ed.). Sinauer Associates/Oxford University Press.
Cargnelutti E., Tomasino B., & Fabbro F. (2022). Effects
of linguistic distance on second language brain activations in
bilinguals: An exploratory coordinate-based
meta-analysis. Frontiers in Human
Neuroscience, 15, 744489.
Crosse, M. J., Di Liberto, G. M., Bednar, A., & Lalor, E. C. (2016). The
Multivariate Temporal Response Function (mTRF) Toolbox: A MATLAB
toolbox for relating neural signals to continuous
stimuli. Frontiers in Human
Neuroscience, 10.
De Bleser, R., Dupont, P., Postler, J., Bormans, G., Speelman, D., Mortelmans, L., & Debrock, M. (2003). The
organization of the bilingual lexicon: A PET
study. Journal of
Neurolinguistics, 16(4–5), 439–456.
Della Rosa, P. A., Videsott, G., Borsa, V. M., Canini, M., Weekes, B. S., Franceschini, R., & Abutalebi, J. (2013). A
neural interactive location for multilingual
talent. Cortex 49, 605–608.
Fedorenko, E., Hsieh, P. J., Nieto-Castañón, A., Whitfield-Gabrieli, S. & Kanwisher, N. (2010). New
method for fMRI investigations of language: Defining ROIs
functionally in individual
subjects. Journal of
Neurophysiology, 104, 1177–1194.
Fred, A. L., Kumar, S. N., Kumar Haridhas, A., Ghosh, S., Purushothaman Bhuvana, H., Sim, W. K. J., Vimalan, V., Givo, F. A. S., Jousmäki, V., Padmanabhan, P., & Gulyás, B. (2022). A
brief introduction to magnetoencephalography Meg and its clinical
applications. Brain
Sci., 12(6), 788.
Geng, S., Quiñones, I., Gil-Robles, S., Pomposo Gastelu, I. C., Bermudez, G., Timofeeva, P., Molinaro, N., Carreiras, M., & Amoruso, L. (2023). Neural
dynamics supporting longitudinal plasticity of action naming across
languages: MEG evidence from bilingual brain tumor
patients. Neuropsychologia, 181, 108494.
Halsband, U., Krause, B. J., Sipilä, H., Teräs, M., & Laihinen, A. (2002). PET
studies on the memory processing of word pairs in bilingual
Finnish–English subjects. Behavioural
Brain
Research, 132(1), 47–57.
Hanna, J., Shtyrov, Y., Williams, J., & Pulvermüller, F. (2016). Early
neurophysiological indices of second language morphosyntax
learning. Neuropsychologia, 82, 18–30.
Hillman, E. (2014). Coupling
mechanism and significance of the BOLD signal: A status
report. Annual Review of
Neurosciences, 37, 161–181.
Hirano, Y., Stefanovic, B., & Silva, A. (2011). Spatiotemporal
evolution of the functional magnetic resonance imaging response to
ultrashort stimuli. Journal of
Neuroscience, 31, 1440–1447.
Hisagi, M., Shafer, V. L., Miyagawa, S., Kotek, H., Sugawara, A., & Pantazis, D. (2016). Second-language
learning effects on the automaticity of speech processing of
Japanese phonetic contrasts: An MEG
study. Brain
Research, 1652, 111–118.
Ihara, A., & Kakigi, R. (2006). Oscillatory
activity in the occipitotemporal area related to the visual
perception of letters of a first/second language and pseudo
letters. NeuroImage, 29(3), 789–796.
Indefrey, P. (2006). A
meta-analysis of hemodynamic studies on first and second language
processing: Which suggested differences can we trust and what do
they mean? Lang.
Learn. 56, 279–304.
Inouchi, M., Kubota, M., Ferrari, P., & Roberts, T. P. L. (2003). Magnetic
mismatch fields elicited by vowel duration and pitch changes in
Japanese words in humans: Comparison between native- and
non-speakers of
Japanese. Neuroscience
Letters, 353(3), 165–168.
Jumah, F. R., & Dossani, R. H. (Updated 2022, Dec. 6). Neuroanatomy,
singulate cortex. On StatPearls
[Internet]. 2024 Jan-. StatPearls Publishing. [URL]
Kim, J.-J., Kim, M. S., Lee, J. S., Lee, D. S., Lee, M. C., & Kwon, J. S. (2002). Dissociation
of working memory processing associated with native and second
languages: PET
investigation. NeuroImage, 15(4), 879–891.
Klein, D. (2003). A
positron emission tomography study of presurgical language mapping
in a bilingual patient with a left posterior temporal cavernous
angioma. Journal of
Neurolinguistics, 16(4–5), 417–427.
Klein, D., Milner, B., Zatorre, R. J., Meyer, E., & Evans, A. C. (1995). The
neural substrates underlying word generation: A bilingual
functional-imaging study. Proceedings
of the National Academy of
Sciences, 92(7), 2899–2903.
Klein, D., Milner, B., Zatorre, R. J., Visca, R., & Olivier, A. (2002). Cerebral
organization in a right-handed trilingual patient with
right-hemisphere speech: a positron emission tomography
study. Neurocase, 8(5), 369–375.
Klein, D., Watkins, K. E., Zatorre, R. J., & Milner, B. (2006). Word
and nonword repetition in bilingual subjects: A PET
study. Human Brain
Mapping, 27(2), 153–161.
Klein, D., Zatorre, R. J., Milner, B., Meyer, E., & Evans, A. C. (1994). Left
putaminal activation when speaking a second language: Evidence from
PET. NeuroReport, 5(17), 2295.
Kubota, M., Ferrari, P., & Roberts, T. P. L. (2003). Magnetoencephalography
detection of early syntactic processing in humans: Comparison
between L1 speakers and L2 learners of
English. Neuroscience
Letters, 353(2), 107–110.
(2004). Human
neuronal encoding of English syntactic violations as revealed by
both L1 and L2 speakers. Neuroscience
Letters, 368(2), 235–240.
Kubota, M., Inouchi, M., Ferrari, P., & Roberts, T. P. L. (2005). Human
magnetoencephalographic evidence of early syntactic responses to
c-selection violations of English infinitives and gerunds by L1 and
L2 speakers. Neuroscience
Letters, 384(3), 300–304.
Leonard, M. K., Brown, T. T., Travis, K. E., Gharapetian, L., Hagler, D. J., Dale, A. M., Elman, J. L., & Halgren, E. (2010). Spatiotemporal
dynamics of bilingual word
processing. NeuroImage, 49(4), 3286–3294.
Leonard, M. K., Torres, C., Travis, K. E., Brown Jr., T. T., D. J. H., Dale, A. M., Elman, J. L., & Halgren, E. (2011). Language
proficiency modulates the recruitment of non-classical language
areas in bilinguals. PLOS
ONE, 6(3), e18240.
Leonard, M., Ferjan Ramirez, N., Torres, C., Hatrak, M., Mayberry, R., & Halgren, E. (2013). Neural
stages of spoken, written, and signed word processing in beginning
second language learners. Frontiers
in Human
Neuroscience, 7. [URL].
Lerch, J., van der Kouwe, A., Raznahan, A., Paus, T., Johansen-Berg, H., Miller, K., Smith, S., Fischl, B., & Sotiropoulos, S. (2017). Studying
neuroanatomy using MRI. Nature
Neuroscience, 20, 314–326.
Li, H., Zhang, J., & Ding, G. (2021). Reading
across writing systems: A meta-analysis of the neural correlates for
first and second language
reading. Bilingualism: Language and
Cognition 24, 537–548.
Lin, J.-F. L., Imada, T., & Kuhl, P. K. (2019). Neuroplasticity,
bilingualism, and mental mathematics: A behavior-MEG
study. Brain and
Cognition, 134, 122–134.
Liu, H., & Cao, F. (2016). L1
and L2 processing in the bilingual brain: A meta-analysis of
neuroimaging studies. Brain and
Language, 159, 60–73.
Lizarazu, M., Carreiras, M., Bourguignon, M., Zarraga, A., & Molinaro, N. (2021). Language
proficiency entails tuning cortical activity to second language
speech. Cerebral
Cortex, 31(8), 3820–3831.
Luck, S. J. (2014). An
introduction to the event-related potential
technique (2nd
ed.). The MIT Press.
Martensson, J., Eriksson, J., Bodammer, N. C., Lindgren, M., Johansson, M., Nyberg, L., & Lovden, M. 2012. Growth
of language-related brain areas after foreign language
learning. NeuroImage, 63, 240–244.
Menning, H., Imaizumi, S., Zwitserlood, P., & Pantev, C. (2002). Plasticity
of the human auditory cortex induced by discrimination learning of
non-native, mora-timed contrasts of the Japanese
language. Learning &
Memory, 9(5), 253–267.
Nørgaard, M., Ganz, M., Svarer, C., Frokjaer, V. G., Greve, D. N., Strother, S. C., & Knudsen, G. M. (2019). Optimization
of preprocessing strategies in Positron Emission Tomography (PET)
neuroimaging: A [11C]DASB PET
study. NeuroImage, 199, 466–479.
Pang, E. W., & MacDonald, M. J. (2012). An
MEG study of the spatiotemporal dynamics of bilingual verb
generation. Brain
Research, 1467, 56–66.
Pellikka, J., Helenius, P., Mäkelä, J. P., & Lehtonen, M. (2015). Context
affects L1 but not L2 during bilingual word recognition: An MEG
study. Brain and
Language, 142, 8–17.
Perani, D., & Cappa, S. F. (2022). The
contribution of Positron Emission Tomography to the study of
aphasia. Handbook of Clinical
Neurology, 185, 151–165.
Phillips, S. F., & Pylkkänen, L. (2021). Composition
within and between languages in the bilingual mind: MEG evidence
from Korean/English
bilinguals. eNeuro, 8(6).
Pihko, E. (2002). Visual
attention to words in different languages in bilinguals: A
magnetoencephalographic
study. NeuroImage, 17(4), 1830–1836.
Quiñones, I., Amoruso, L., Pomposo Gastelu, I. C., Gil-Robles, S., & Carreiras, M. (2021). What
can glioma patients teach us about language (re)organization in the
bilingual brain: Evidence from fMRI and
MEG. Cancers, 13(11), Article
11.
Raboyeau, G., Marie, N., Balduyck, S., Gros, H., Démonet, J.-F., & Cardebat, D. (2004). Lexical
learning of the English language: A PET study in healthy French
subjects. NeuroImage, 22(4), 1808–1818.
Sebastian, R., Laird, A. R., & Kiran, S. (2011). Meta-analysis
of the neural representation of first language and second
language. Applied
Psycholinguistics, 32(4), 799–819.
Stein, M., Federspiel, A., Koenig, T., Wirth, M., Strik, W., Wiest, R., Brandeis, D., & Dierks, T. 2012. Structural
plasticity in the language system related to increased second
language
proficiency. Cortex, 48, 458–465.
Stowe, L. A., Wijers, A. A., Willemsen, A., Reuland, E., Paans, A. M. J., & Vaalburg, W. (1994). PET
studies of language: An assessment of the reliability of the
technique. Journal of
Psycholinguistic
Research, 23(6), 499–527.
Sulpizio, S., Del Maschio, N., Fedelia, D., & Abutalebi, J. (2020). Bilingual
language processing: A meta-analysis of functional neuroimaging
studies. Neuroscience and
Biobehavioral
Reviews, 108, 834–853.
Tai, Y. F., & Piccini, P. (2004). Applications
of positron emission tomography (PET) in
neurology. Journal of Neurology,
Neurosurgery, and
Psychiatry, 75(5), 669–676.
Tian, L., Chen, H., Heikkinen, P. P., Liu, W., & Parviainen, T. (2023). Spatiotemporal
dynamics of activation in motor and language areas suggest a
compensatory role of the Motor Cortex in Second Language
Processing. Neurobiology of
Language, 4(1), 178–197.
Uddin, L. Q., Nomi, J. S., Hébert-Serpian, B., Ghaziri, J., & Boucher, O. (2017). Structure
and function of the human
insula. Journal of Clinical
Neurophysiology: Official Publication of the American
Electroencephalographic
Society, 34(4), 300–306.
Wang, Y., Xiang, J., Vannest, J., Holroyd, T., Narmoneva, D., Horn, P., Liu, Y., Rose, D., deGrauw, T., & Holland, S. (2011). Neuromagnetic
measures of word processing in bilinguals and
monolinguals. Clinical
Neurophysiology, 122(9), 1706–1717.
Weiss, E., Kann, M., & Wang, Q. (2023). Neuromodulation
of neural oscillations in health and
disease. Biology, 12(3), 371.
Xiang, H., van Leeuwen, T. M., Dediu, D., Roberts, L., Norris, D. G., Hagoort, P. 2015. L2-proficiency-dependent
laterality shift in structural connectivity of brain language
pathways. Brain
Connect, 5, 349–361.
